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Mewtwo was created by humans 20 years before, but he managed to escape. Months before the events of the film, Harry Goodman was recruited by Howard Clifford to track down Mewtwo, which eventually led to his capture. Trapped in a spherical chamber, Mewtwo was used by Dr. However, Mewtwo was freed by Harry and his partner Pikachu, making Mewtwo realize that not all humans are evil. When Harry's car crashed in an ambush , Mewtwo came to his rescue and combined a dying Harry into Pikachu's body but also erased his memory, creating Detective Pikachu as a result. When Detective Pikachu was critically injured, a group of Bulbasaur brought Harry's son Tim , as well as Detective Pikachu, to Mewtwo's location, where he healed Pikachu. But before Mewtwo was able to fully reveal the secret of Harry's case, he was captured and taken away by Howard's men. Mewtwo tried to warn Tim to run before his body was taken over.